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| TAMOXIFEN CITRATE | |||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 10540-29-1
(Base) 54965-24-1 (Citrate) |
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| EINECS NO. | 234-118-0, 259-415-2 | ||
| FORMULA | C26H29NO·C6H8O7 | ||
| MOL WT. | 563.65 | ||
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | Genox; Kessar; Nolvadex; | ||
| (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-hydroxy-1,2,3- propanetricarboxylate (1:1); (Z)-[2-[4-(1,2-diphenylbut-1-enyl) phenoxy]ethyl] dimethylammonium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate; trans-1-(p-beta-Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate; (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine citrate; | |||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
white to off-white crystalline powder |
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| MELTING POINT | 143 - 146 C | ||
| BOILING POINT | |||
| SPECIFIC GRAVITY | |||
| SOLUBILITY IN WATER | Insoluble | ||
| pH | |||
| VAPOR DENSITY |
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| AUTOIGNITION |
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REFRACTIVE INDEX |
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| FLASH POINT | |||
| STABILITY |
Stable under ordinary conditions. |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Tamoxifen and its metabolite 4-hydroxytamoxifen are nonsteroidal selective
estrogen receptor modulators (SERMs) which mimic the action of estrogen in
cardiovascular system and skeletal system. It blocks estradiol-stimulated VEGF
production in breast tumor and acts as an anti-estrogen and antineoplastic in
breast tissue; used in the palliative treatment of breast cancer in
postmenopausal women and to stimulate ovulation in infertility. The chemical
designation of tamoxifen is
(Z)-2-[4-(1,2-diphenyl-1-butenyl) phenoxy]-N,N- dimethylethanamine. The trans form
is active. The citrate salt of tamoxifen is a white to off-white crystalline
powder; insoluble in water; freely soluble in glacial acetic acid; slightly
sobuble in alcohol, acetone; oral antiestrogen.
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| SALES SPECIFICATION | |||
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APPEARANCE |
fine off-white crystalline powder |
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IDENTIFICATION |
Complies Test A,B |
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| PURITY |
99.0% min (trans-Form 99.0% min + cis-Form 1.0% max) |
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| MELTING POINT |
143 - 146 C |
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RELATED SUBSTANCE |
1.0% max |
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LOSS ON DRYING |
0.5% max |
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RESIDUE ON IGNITION |
0.2% max | ||
| TRANSPORTATION | |||
| PACKING |
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| HAZARD CLASS | |||
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| OTHER INFORMATION | |||
| Hazard Symbols: T, Risk Phrases: 45-60-61-22-64, Safety Phrases: 53-36/37/39-45 | |||
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